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General Thoracic Surgery

Overview

Our department covers various thoracic diseases which require surgery or endoscopic intervention, such as thoracic malignancies, infections, and pulmonary dysfunction. As lung cancer, the central theme of us since 1962, molecular targets for multi-disciplinary strategy are investigated. Especially idiopathic pulmonary fibrosis-concomitant lung cancer is a challenging issue. For respiratory dysfunction, both lung transplantation and regenerative medicine are our objects. Murine orthotopic transplant model has been established in our laboratory, and prevention of the allogeneic rejection is studied. Compensatory lung growth after surgery is a key to lung regenerative research, and both radiologic approaches for clinical cases and type-II alveolar cell are investigated.

Professor:
Ichiro Yoshino, M.D., Ph.D.

TEL:+81-43-222-7171
FAX:+81-43-226-2172
e-mail:iyoshino●faculty.chiba-u.jp
URL: https://www.m.chiba-u.jp/dept/general-thoracic-surgery/

※　Please change "●" mark to at-mark if you send emails.

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Research & Education

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  1. Diagnosis, surgery and multi-disciplinary treatments for thoracic malignancies such as lung cancer, mediastinal tumors, chest wall tumor, pleural tumors, etc.
  2. Analysis of molecular mechanisms in lung carcinogenesis and progression of lung cancer, especially the case accompanied by micropapillary component(MPP) in the tumor tissues and interstitial lung diseases in the background (partly collaborated with Prof. Kaneda, Dept. of Molecular Oncology)
  3. Basic and clinical investigation of immunotherapy by activation of NKT cells for non-small cell lung cancer (collaborated by Prof. Motohashi, Dept. of Medical Immunology)
  4. Artifical intelligence application for lung cancer surgery (collaborated by Prof. Kawakami, Dept. of Artificial intelligence medicine)
  5. Development of bronchoscopic interventions and instruments
  6. Elucidation of mechanism and development of prevention for allogeneic rejection of transplanted lung

Recent Publications

  • Saji H, Okada M, Tsuboi M, Nakajima R, Suzuki K, Aokage K, Aoki T, Okami J, Yoshino I, Ito H, Okumura N, Yamaguchi M, Ikeda N, Wakabayashi M, Nakamura K, Fukuda H, Nakamura S, Mitsudomi T, Watanabe SI, Asamura H; West Japan Oncology Group and Japan Clinical Oncology Group. Segmentectomy versus lobectomy in small-sized peripheral non-small-cell lung cancer (JCOG0802/WJOG4607L): a multicentre, open-label, phase 3, randomised, controlled, non-inferiority trial. Lancet. 2022 Apr 23;399(10335):1607-1617.
  • Hata A, Nakajima T, Matsusaka K, Fukuyo M, Nakayama M, Morimoto J, Ito Y, Yamamoto T, Sakairi Y, Rahmutulla B, Ota S, Wada H, Suzuki H, Iwata T, Matsubara H, Ohara O, Yoshino I, Kaneda A. Genetic alterations in squamous cell lung cancer associated with idiopathic pulmonary fibrosis. Int J Cancer. 2021 Jun 15;148(12):3008-3018.
  • Hata A, Suzuki H, Nakajima T, Fujiwara T, Shiina Y, Kaiho T, Toyoda T, Inage T, Ito T, Sakairi Y, Tamura H, Wada H, Yamada Y, Chiyo M, Matsusaka K, Fukuyo M, Shinohara KI, Itoga S, Motohashi S, Matsushita K, Kaneda A, Yoshino I. Differential gene analysis during the development of obliterative bronchiolitis in a murine orthotopic lung transplantation model: A comprehensive transcriptome-based analysis. PLoS One. 2020 May 8;15(5):e0232884.