EN
ページタイトル画像

Public Health

Overview

We aim to elucidate the causes, establish diagnostic methods, and realize precision medicine by identifying genes related to the onset, aggravation, and responsiveness to treatment of diseases with unknown etiology and intractable diseases. Our targets include both polygenic and monogenic diseases and several collaborative projects with clinical sections are on-going.

Professor:
Yoshihiro Onouchi, M.D., Ph.D.

TEL: +81-43-226-2067
FAX: +81-43-226-2070
e-mail: onouchy●chiba-u.jp
URL: http://www.m.chiba-u.ac.jp/class/pubheal/

※　Please change "●" mark to at-mark if you send emails.

32.jpg

Research & Education

  • Identification of genes relevant to Kawasaki disease (susceptibility, coronary artery complication)
  • Identification of genes relevant to Inflammatory bowel disease (susceptibility, treatment efficacy)
  • Next Generation Sequencing of B cell receptor repertoire in Kawasaki disease patients
  • Development of precision medicine for Kawasaki disease by using genetic information
  • Genetic counseling of various genetic diseases
  • Clinical genetics
32図.jpg

Recent Publications

  • Johnson TA, Onouchi Y et al. Association of an IGHV3-66 gene variant with Kawasaki disease. J Hum Genet. 66, 475-489. 2021.
  • Hamada H, Suzuki H, Onouchi Y et al. Efficacy of primary treatment with immunoglobulin plus ciclosporin for prevention of coronary artery abnormalities in patients with Kawasaki disease predicted to be at increased risk of non-response to intravenous immunoglobulin (KAICA): a randomised controlled, open-label, blinded-endpoints, phase 3 trial. Lancet. 393, 1128-1137, 2019.
  • Thiha K, Onouchi Y et al. Investigation of novel variations of ORAI1 gene and their association with Kawasaki disease. J Hum Genet. 64, 511-519, 2019.
  • Onouchi Y, Hata A et al. Variations in ORAI1 gene associated with Kawasaki disease. PLoS One. 11, e0145486, 2016.
  • Liu JZ, Yamazaki K et al. Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. Nat Genet. 47, 979-986, 2015.
  • Onouchi Y, Hata A et al. A genome-wide association study identifies three new risk loci for Kawasaki disease. Nat Genet. 44, 517-521, 2012.