EN
ページタイトル画像

Pharmacotherapy

Overview

　Our laboratory work is focused on both basic research and clinical problems. We aim to clarify the pathogenesis of vascular diseases concerning atherosclerosis using molecular biological approach, and to develop a new pharmacotherapy on vascular events. We also aim to solve the clinical problems especially on individual pharmacotherapy and to create the new evidences. We are trying to investigate pharmacokinetics of various drugs such as antibiotics, antitumor agents and anti-epileptics for the purpose of personalized medication. In addition, we develop database of drug-specific laboratory data for checking usage and dosage of prescribed drugs.

Professor:
Itsuko Ishii, Ph.D.

TEL: +81-43-226-2347
FAX: +81-43-226-2347
e-mail: iishii●faculty.chiba-u.jp
URL: http://www.ho.chiba-u.ac.jp/pharmacy/

※　Please change "●" mark to at-mark if you send emails.

40.jpg

Research & Education

  1. Research on vascular diseases using macrophages and smooth muscle cells
  2. Development of novel formulation for unmet medical needs
  3. Research on the effectiveness and safety of antitumor drugs based on pharmacogenomics and pharmacokinetics
  4. Analysis of pharmacokinetics under impaired conditions of organs
  5. Development of database of drug-specific laboratory data for checking prescription
  6. Nurturing of pharmacists as specialists in infection, cancer chemotherapy, and other fields
  7. Residency program for new pharmacists
  8. Clinical practice for pharmaceutical students
40図1.jpg

In vitro CHDF circuit model

40図2.jpg

Laboratory data on the outpatient prescription

40図3.jpg

Locations of acrolein-conjugated amino acid residues

Recent Publications

  1. Uchida M, Sawada M, Yamazaki S, Suzuki T, Suzuki T, Ishii I. Contribution of diafiltration and adsorption to vancomycin clearance in a continuous hemodiafiltration circuit model in vitro. Artif Organs. (In press)
  2. Niibe Y, Suzuki T, Yamazaki S, Uchida M, Suzuki T, Takahashi N, Hattori N, Nakada TA, Ishii I. Identification of factors affecting meropenem pharmacokinetics in critically ill patients: Impact of inflammation on clearance. J Infect Chemother. (In press)
  3. Kobayashi M, Watanabe K, Suzuki T, Dohmae N, Fujiyoshi M, Uchida M, Suzuki T, Igarashi K, Ishii I. Analysis of the acrolein-modified sites of apolipoprotein B-100 in LDL. Biochim Biophys Acta Mol Cell Biol Lipids. 1866:158809, 2021
  4. Yokoyama I, Yamaguchi H, Yamazaki K, Sekiya M, Arai S, Nakamura T, Suzuki T, Ishii I. Usability assessment of drug-linking laboratory data listed on prescriptions for outpatients of chiba university hospital. Sci Rep. 11(1):1715, 2021