Pharmacology
Overview
Pharmacotherapy occupies an essential part of medicine, where transporters have been established as a key drug target molecule in various diseases, such as hypertension, hyperuricemia, diabetes, depression, cancers, and cerebral ischemic injury. In order to seek a new opportunity toward innovative drug development, we are working on a variety of research aiming at clarification of physiological as well as pathophysiological roles of transporters expressed in various tissues. In addition, we also conduct a research to clarify the regulatory mechanisms of food intake and water intake by using physiological and pathophysiological model animals with molecular and biological techniques.
Professor:
Naohiko Anzai, M.D., Ph.D.
TEL:+81-43-226-2050
FAX:+81-43-226-2052
e-mail:afga5078●faculty.gs.chiba-u.jp
URL: https://www.m.chiba-u.ac.jp/class/pharmacology/
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Research & Education
- Characterization of clinico-pathological and pharmacological roles of transporters, including L-type amino acid transporters, in various tissues and cancers.
- Development of new anti-cancer agents/strategy targeting to cancer-associated transporter gene products and their functions.
- Development of new non-invasive diagnostic methods for determination of serum metabolites, which are substrates of transporters.
- Roles of neuropeptides in regulation of food intake and water intake in physiology and pathophysiology.
- Roles of monocarboxylate transporters (MCTs) in cerebral ischemic injury.
Recent Publications
- Hirayama Y, Anzai N, Koizumi S. Mechanisms underlying sensitization of P2X7 receptors in astrocytes for induction of ischemic tolerance. Glia. 2021; 69: 2100-2110.
- Kaneko M, Reien Y, Morio H, Fukuuchi T, Kaneko K, Hirayama Y, Hashimoto H, Kuwata N, Mitsuya H, Anzai N. Effects of islatravir (4'-ethynyl-2-fluoro-2'-deoxyadenosine or EFdA) on renal tubular cells and islatravir's interactions with organic anion transporters. J Pharmacol Sci. 2021; 146: 82-7.
- Morio H, Reien Y, Hirayama Y, Hashimoto H, Anzai N. Protein kinase C activation upregulates human L-type amino acid transporter 2 function. J Physiol Sci. 2021; 71:11.