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Pediatrics

Overview

We provide general and advanced medical care for children, and have staffs in 7 specialized fields. We are mainly conducting research related to immunological/allergic diseases including Kawasaki disease, with a central focus on clarifying the pathogenic mechanisms of allergy and therapeutic intervention, pathophysiology of vasculitis in Kawasaki disease and its therapeutic options, new approach to analysis of brain development by MRI, pathogenesis and epidemiology of invasive bacterial infection due to Haemophilus influenzae and Pneumococcus, pediatric cancer studies, endocrinological disorders such as mineral and glucose metabolism, and all aspects of neonatology, fetal medicine and developmental biology. Intergroup collaboration is encouraged to promote research activities in our department. Collaboration with basic scientists in Chiba University and companies is one of the characteristics of our department.

Professor:
Hiromichi Hamada, MD, Ph.D, FAHA

TEL: +81-43-226-2144
FAX: +81-43-226-2145
e-mail: hamada.hiromichi●chiba-u.jp
URL: http://www.pediatrics-chiba-u.org/

※　Please change "●" mark to at-mark if you send emails.

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Research & Education

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We are doing clinical and basic research. Main research themes are;

  1. Mechanism and risk factors for development of allergy, and its prevention/early intervention Cytokines, function of lymphocytes, signal transduction and regulation of gene expression.
  2. Birth cohort studies, genetic, viruses, and environmental factors for child diseases
  3. Kawasaki disease: mechanism of vasculitis and its clinical application
  4. Explore brain development by new analysis methods using MRI
  5. Vaccination for pediatric patients with underlying choronic illness
  6. Comprehensive treatment for pediatric cancers and its new treatment options
  7. Endocrinological disorders such as mineral and glucose metabolism, pediatric diabetes
  8. Neonatology, fetal medicine and developmental biology

Recent Publications

  1. Takeshita T, et al. Immunogenicity and safety of routine 13-valent pneumococcal conjugate vaccination outside recommended age range in patients with hematological malignancies and solid tumors. Vaccine 2022;  doi: 10.1016/j.vaccine.2022.01.056.
  2. Shiohama T, et al. Decreased head circumference at birth associated with maternal tobacco smoke exposure during pregnancy on the Japanese prospective birth cohort study. Sci Rep 2021;11:18949
  3. Nakano T, et al. Breastfeeding promotes egg white sensitization in early infancy. Pediatr Allergy Immunol 2020;31:315.
  4. Aoki T, et al.　Activated invariant natural killer T cells directly recognize leukemia cells in a CD1d-independent manner. Cancer Sci 2020;111:2223.
  5. Hamada H, et al. Efficacy of primary treatment with immunoglobulin plus ciclosporin for prevention of coronary artery abnormalities in patients with Kawasaki disease predicted to be at increased risk of non-response to intravenous immunoglobulin (KAICA): a randomised controlled, open-label, blinded-endpoints, phase 3 trial. Lancet 2019; 393(10176):1128.
  6. Takatani R, et al. A novel CUL7 mutation in a Japanese patients with 3M synderome. Hum Genome Var 2018;5:30