EN
ページタイトル画像

Molecular Virology

Overview

Tumor virus study has contributed to the clarification of carcinogenic mechanisms. In our department, we have been conducting research on carcinogenic mechanisms of the tumor virus, papillomavirus. Carcinogenic mechanism study of viruses also provides clues to clarify characteristics of human cancers that are not caused by viruses.
Furthermore, tumor virus study has also provided the basic technology and knowledge to develop viruses that kill cancer (oncolytic viruses). In our department, we are conducting research on viruses to cure cancer based on achievements in this tumor virus study.

Associate Professor:
Kengo Saito

TEL: +81-43-226-2043
FAX: +81-43-226-2045
e-mail:saitok●chiba-u.jp
URL: http://www.m.chiba-u.ac.jp/dept/virology/

※　Please change "●" mark to at-mark if you send emails.

22.jpg

Research & Education

Research

  1. Sindbis virus as an oncolytic virus
    　•Oncolytic activity of Sindbis virus (SIN) structural proteins
    　•Oncolytic activity of Sindbis virus (SIN) replicon
    　•Preclinical study of oncolytic viruses
  2. Papillomaviruses
    　•Functions of HPV-16 E6 protein
    　•Functions of bovine papillomavirus (BPV) E5 protein
  3. Hepatitis viruses

Education

  1. Virology for medical students
  2. Medical Science Research for medical students
22図.jpg

Tumor-specific detection and lysis by GFP-SIN (Sindbis virus expressing GFP) i.v. injection. Nude mice bearing C33A tumors received single i.v. injection of GFP-expressing recombinant SIN (GFP-SIN) or DMEM(mock). Bright-images and fluorescent images of representative tumors at 3, 5, 10, and 18 days after infection. The tumor of mice that received GFP-SIN injection disappeared at day-18.

Recent Publications

  • Sindbis viral structural protein cytotoxicity on human neuroblastoma cells. Saito EY, Saito K, Hishiki T, Takenouchi A, Saito T, Sato Y, Terui K, Matsunaga T, Shirasawa H, Yoshida H. Pediatr Surg Int., 2020, 1173-1180.
  • Surveillance of immunity acquired from poliovirus immunization including vaccination with the Sabin strain-derived inactivated vaccine. Hotta C, Ogawa T, Shirasawa H. Hum Vaccine Immunother. 2019 Jan 24:1-6.
  • Alteration of cell cycle progression by Sindbis virus infection. Yi R, Saito K, Isegawa N, Shirasawa H. Biochem Biophys Res Commun. 2015;462:426-32.
  • TP53 codon 72 polymorphism and cervical cancer: pooled analysis of individual data of 15 834 women from 49 studies. Stefanie J. Klug et al., Lancet Oncology, 10, 772-784, 2009.