Medical Physiology
Overview
In the department of medical physiology, we are currently conducting research on the regulatory mechanisms of glucose and energy metabolism, by using molecular biology and developmental engineering techniques. Our scientific interest covers a variety of metabolic disorders, including diabetes mellitus, obesity and eating disorders. We put a high value on unveiling the intra- and inter-cellular signaling pathways to maintain metabolic homeostasis in each hierarchy of molecules, cells, organs and individuals. We are also interested in research for a novel therapeutic strategies and/or agents by which the medical technology would greatly be improved.
Professor:
Takashi Miki, M.D., Ph. D.
TEL: +81-43-226-2029
FAX: +81-43-226-2034
e-mail: tmiki●faculty.chiba-u.jp
URL: https://www.m.chiba-u.jp/dept/physiology/
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Research & Education
- Regulation of glucose metabolism and energy homeostasis
- Molecular dissection of exocytosis
- Physiological analysis of insulin secretion and action using genetically engineered mouse models
- Regulation of cell firing of electrically excitable cells
- Metabolic regulation via signal crosstalk between brain and peripheral tissues
- Pathogenesis of metabolic syndrome and diabetes mellitus
- Search for novel therapeutic targets of diabetes mellitus
Recent Publications
- ‘Gs/Gq signaling switch in β-cells defines incretin effectiveness in diabetes.’ Oduori O, et al.. (2020) J. Clin. Invest. 130(12):6639-6655, 2020.
- ‘GPR52 accelerates fatty acid biosynthesis in a ligand-dependent manner in hepatocytes and in response to excessive fat intake in mice.’ Wada M, et al.. (2021) iScience 24(4):102260.
- ‘Lack of brain insulin receptor substrate-1 causes growth retardation, with decreased expression of growth hormone-releasing hormone in the hypothalamus, Hayashi T, et al.. (2021) Diabetes. 70(8):1640-1653.
- ‘Lecithin Inclusion by α-Cyclodextrin Activates SREBP2 Signaling in the Gut and Ameliorates Postprandial Hyperglycemia.’ Lee E, et al.. (2021) Int J Mol Sci 6;22(19):10796.