Endocrinology, Hematology and Gerontology
Overview
Department of Endocrinology, Hematology and Gerontology aims at patient-centered care in complex disorders based on the highest standards of academic medicine. We provide the best possible treatment with common to relatively rare diseases through a team-based approach. We carry out the basic science and clinical studies covering a broad range of areas in diabetes, metabolism, endocrinology, gerontology and hematology to develop novel therapeutic strategies for currently untreatable diseases. Through our integrated research, education, community-outreached programs and global collaboration, we are dedicated to pursue the cutting edge of medical science.
Professor:
Koutaro Yokote, MD, PhD, MBA
TEL: +81-43-226-2092
FAX: +81-43-226-2095
e-mail: ninai●office.chiba-u.jp
URL: http://www.m.chiba-u.jp/class/clin-cellbiol/
※ Please change "●" mark to at-mark if you send emails.
Research & Education
Diabetes, Metabolism, Endocrinology and Gerontology
- Pathogenesis and treatment of type 2 diabetes.
- Molecular mechanism of diabetic complications: the role of transcription factors.
- Insulin action in the liver, adipose tissue and brain.
- Obesity research: from molecular mechanisms to clinical trials.
- Dyslipidemia and atherosclerosis.
- Intracellular signaling in regulation of proliferation and apoptosis of endocrine cells.
- Advanced research for osteoporosis and bone metabolism.
- Generation of endocrine cells from ES/iPS cells.
- Molecular pathogenesis and treatment of adrenal diseases.
- Molecular mechanism of aging: pathogenesis and treatment of progeroid Werner syndrome.
Hematology
- POEMS (Crow-Fukase) syndrome.
- Pathogenesis of POEMS syndrome.
- Clinical trial with autologous peripheral blood transplantation. - Clinical trials in hematopoietic stem cell transplantation.
- Mechanism of leukemogenesis by MLL-ELL fusion gene.
- Mechanism of chronis myeloproliferative disorders (CMPD) development.
- Analysis of newly-identified TEL-Lyn fusion gene in idiopathic myelofibrosis.
Recent Publications
- Takeda K, Ono H et al. Central administration of sodium-glucose cotransporter-2 inhibitors increases food intake involving adenosine monophosphate-activated protein kinase phosphorylation in the lateral hypothalamus in healthy rats. BMJ Open Diabetes Res Care. 2021;9:e002104.
- Ishiwata K, Koide H et al. Characteristics of benign adrenocortical adenomas with 18F-FDG PET accumulation. Eur J Endocrinol. 2021:185:155-165.
- Ide S, Maezawa Y et al. Transcription factor 21 is required for branching morphogenesis and regulates the GDNF-axis in kidney development. J Am Soc Nephrol. 2018;29:2795-2808.
- Mishina T, Sakaida E et al. Genetic subtype classification using a simplified algorithm and mutational characteristics of diffuse large B-cell lymphoma in a Japanese cohort. Br J Haematol. 2021;195(5):731-742.
- Wilding JPH, Yokote K et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021:384:989-1002.zz