General Surgery
Overview
Our laboratory is conducting researches aiming at improving the outcome of surgical resection for hepatobiliary, pancreas, and breast diseases. Especially for the advanced hepato-biliary-pancreatic malignancies, aggressive surgical resection in combination with multidisciplinary treatment has been carried out, and benefits of chemotherapies followed by radical surgery have been published in several studies. Severe postoperative complications are important issues after hepato-biliary-pancreatic surgery. For clarifying the mechanisms of postoperative complications, we have developed perioperative management including safer resection method and perioperative nutritional management. In contrast, we also perform minimally invasive surgery such as laparoscopic hepato-biliary-pancreatic surgery. In addition, we aggressively perform living and deceased donor liver transplantation for end-stage liver diseases. We also studied how to improve the patient's quality of life by carrying out breast-conserving surgery which reduces the range of resection without losing curability in the region of the breast. For improving the prognosis of breast cancer, we are conducting the basic studies focusing on tumor proliferation, invasion, and metastasis. Through these studies, we have reported a number of clinical and basic research results, and contributed to develop new treatment options in this area.
Professor:
Masayuki Ohtsuka, M.D., Ph.D.
TEL: +81-43-226-2103
FAX: +81-43-226-2552
e-mail: otsuka-m●faculty.chiba-u.jp
URL: http://www.m.chiba-u.ac.jp/dept/zoukiseigyo/
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Research & Education
- Hepato-biliary-pancreatic surgery
Surgical treatment and chemotherapy for hepato-biliary-pancreatic malignancy
Immunonutrition during hepato-biliary- pancreatic surgery
Laparoscopic hepatectomy and pancreatectomy
Surgical treatment for duodenal tumor, portal hypertension, and spleen.
Molecular mechanisms of tumor proliferation, invasion, and metastasis.
Surgical stress after hepato-biliary-pancreatic surgery - Organ transplantation
Living and deceased donor liver transplantation
Cellular and organ regeneration after transplantation - Breast surgery
Diagnostic and surgical strategies for breast cancer
Molecular mechanisms of the progression of breast cancer
Recent Publications
- Hosokawa I, Furukawa K, Takayashiki T, Kuboki S, Takano S, Miyazaki M, Ohtsuka M. Surgical implications of the confluence patterns of the left intrahepatic bile ducts in right hepatectomy for perihilar cholangiocarcinoma. J Hepatobiliary Pancreat Sci 2021 (in press)
- Furukawa A, Furukawa K, Suzuki D, Yoshitomi H, Takayashiki T, Kuboki S, Miyazaki M, Ohtsuka M. Effect of immunonutrition on infectious complications in low skeletal muscle mass patients after pancreaticoduodenectomy. Clin Nutr 2021;40:103-109.
- Sasaki K, Takano S, Tomizawa S, Miyahara Y, Furukawa K, Takayashiki T, Kuboki S, Takada M, Ohtsuka M. C4b-binding protein α-chain enhances antitumor immunity by facilitating the accumulation of tumor-infiltrating lymphocytes in the tumor microenvironment in pancreatic cancer. J Exp Clin Cancer Res. 2021;40:212.
- Suda R, Sakai N, Matsushita K, Ishige T, Kawasaki Y, Shiko Y, Furukawa K, Mishima T, Nakadai E, Ohtsuka M. Prediction of mismatch repair deficient biliary tract cancer: Role of morphological features and host immune response detected by routine hematoxylin-eosin staining. J Hepatobiliary Pancreat Sci. 2021;28:680-691.
- Masuda T, Fujimoto H, Teranaka R, Kuroda M, Aoyagi Y, Nagashima T, Sangai T, Takada M, Nakagawa A, Kubota Y, Yokote K, Ohtsuka M. Anti-HER2 antibody therapy using gene-transduced adipocytes for HER2-positive breast cancer. Breast Cancer Res Treat. 2020;180:625-634.