Dermatology
Overview
The mission of the department of dermatology in Chiba University is to provide a better environment and tools to achieve the following objectives and goals:
- To provide the most appropriate medical treatment for patients who visit our department.
- To help develop dermatologists with high ethical standards and responsibilities for patient care and always with skills to improve diagnostic and treatment techniques.
- To better understand a wide range of abnormal skin conditions in addition to normal skin by cutting-edge science and ultimately to develop better treatments.
Professor:
Takashi Inozume
TEL: +81-43-226-2505
FAX: +81-43-226-2128
e-mail:tinozume●chiba-u.jp
URL: http://www.m.chiba-u.ac.jp/class/dermatology/index.html
※ Please change "●" mark to at-mark if you send emails.
Research & Education
・Our research interests are to understand anti-melanoma T-cell response.
Especially, we are focusing on the characteristics of melanoma specific tumor infiltrating T-cells (TILs) derived from responders of immune checkpoint inhibitors (ICIs), to develop the novel immunotherapy for melanoma.
Our current specific aims are:
- Identify the novel immune checkpoint molecules that control anti-melanoma T-cell response.
- Identify the markers specifically expressed on the melanoma specific TILs that play important roles in anti-melanoma immune response.
- Develop the methods to activate melanoma specific TILs selectively.
Recent Publications
- PD-1 blockade therapy promotes infiltration of tumor-attacking exhausted T cell clonotypes. Nagasaki J, Inozume T, Togashi Y et al. Cell Rep. 2022;38:110331.
- TIGIT/CD155 axis mediates resistance to immunotherapy in patients with melanoma with the inflamed tumor microenvironment. Kawashima S, Inozume T, Togashi Y et al. J Immunother Cancer. 2021;9:e003134.
- Analysis of the Tumor Reactivity of Tumor-Infiltrating Lymphocytes in a Metastatic Melanoma Lesion that Lost Major Histocompatibility Complex Class I Expression after Anti-PD-1 Therapy. Inozume T, Yaguchi T, Togashi Y et al. J Invest Dermatol. 2019;139:1490-1496.