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Allergy and Clinical Immunology

Overview

　Pathological conditions of refractory allergic or autoimmune diseases are being clarified on a molecular level due to the recent progress in molecular biology. However, many patients with allergic or autoimmune diseases are still forced to undergo treatment with steroids or immunosuppressants, which may be accompanied by significant adverse drug reactions.
　We consider that medical research will go in the right direction if basic research and clinical medicine are implemented, and bidirectional interactions from basic research to clinical medicine, and vice versa, are maintained. Our department intends to develop new therapeutic strategies for refractory autoimmune and allergic diseases by optimizing the network between basic research and clinical medicine.

Professor:
Hiroshi Nakajima, M.D., Ph.D.

TEL: +81-43-226-2198
FAX: +81-43-226-2199
e-mail: nakajimh●faculty.chiba-u.jp
URL: http://www.m.chiba-u.jp/dept/allergy-clin-immunol/

※　Please change "●" mark to at-mark if you send emails.

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Research & Education

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  1. Mechanisms underlying allergic inflammation in asthma
    a) Roles of epithelial STAT3 in allergic airway inflammation
    b) Regulation of GATA3 expression during asthmatic responses
    c) Roles of innate memory in allergic airway inflammation
  2. Molecular mechanisms of regulatory T cell differentiation
    a) Roles of p63 in Treg differentiation
    b) Roles of TSLP in Treg cell differentiation
    c) Roles of Ascl2 in Tfr cell differentiation
  3. Mechanisms underlying autoimmune diseases
    a) Roles of Semaphorins in autoimmune arthritis
    b) Roles of type I IFNs in autoimmune diseases
  4. Clinical research
    a) Immune responses to Vaccines in patients with autoimmune diseases
    b) Femur head necrosis in ANCA-associated vasculitis
    c) LoVAS follow-up (to evaluate the effects of rituximab in the initial treatment of MPA)

Recent Publications

  1. Tanaka S, Suto S, Iwamoto T, Kageyama T, Tamachi T, Takatori H, Suzuki K, Hirose K, Ohara O, Lefebvre V, Nakajima H. Sox12 promotes Treg differentiation in the periphery during colitis. J Exp Med. 2018;215:2509-19.
  2. Saku A, Hirose K, Ito T, Iwata A, Sato T, Kaji H, Tamachi T, Suto A, Goto Y, Domino SE, Narimatsu H, Kiyono H, Nakajima H. Fucosyltransferase 2 induces lung epithelial fucosylation and exacerbates house dust mite-induced airway inflammation. J Allergy Clin Immunol. 2019;144:698-709.e9.
  3. Furuta S, Nakagomi D, Kobayashi Y, Hiraguri M, Sugiyama T, Amano K, Umibe T, Kono H, Kurasawa K, Kita Y, Matsumura R, Kaneko Y, Ninagawa K, Hiromura K, Kagami SI, Inaba Y, Hanaoka H, Ikeda K, Nakajima H; LoVAS Collaborators. Effect of reduced-dose vs high-dose glucocorticoids added to rituximab on remission induction in ANCA-associated vasculitis: A randomized clinical trial. JAMA. 2021;325:2178-87.